Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

 

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders  in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first  publication  to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No. PDF_01553_Evgin Lab_2024_06_06

A postdoctoral research fellow position is immediately available in the Genome Sciences Department at the BC Cancer Research Institute in the group of Dr. Laura Evgin. The overarching goal of the Evgin lab is to make T cell therapies for cancer more effective and accessible. We are developing novel CAR T cell strategies for both hematologic and solid cancers.

• Using immune competent mouse models that are highly representative of human lymphoma, we are modelling clinical correlates of CD19 CAR T cell treatment failure to understand the underlying mechanisms and implement engineering solutions.
• The introduction of a CAR confers a new specificity to a T cell; however, the native T cell receptor (TCR) remains intact in all approved autologous cell products. Therefore, CAR T cells have dual specificity. We are using vaccines to stimulate CAR T cells through their native T cell receptor to enhance engraftment and function and improve tumour control.
• Currently approved CAR T cell therapies are manufactured in a bespoke manner by lentivirus or retrovirus transduction of autologous T cells ex vivo. While the approach has generated impressive clinical benefits, the financial burden and logistical difficulties have limited broad implementation. We are collaborating with local experts in RNA and lipid nanotechnology to develop strategies to generate CAR T cells in vivo.
• We are testing novel CAR T cell designs for the treatment of cancers and autoimmune diseases including lupus.

We are looking for a motivated, creative, and meticulous individual who has a strong understanding of molecular biology and immunology to contribute to our research program. Our lab is committed to creating a welcoming environment where everyone feels valued and respected, regardless of race, ethnicity, gender, sexual orientation, religion, age, or abilities.

Responsibilities

The candidate will be responsible for performing standard and investigative laboratory work, including, following detailed, time-sensitive and challenging protocols to generate lymphoma or lupus mouse models and adoptive transfer experiments. The candidate will conduct flow-based immunologic phenotyping experiments and tumor measurements by a variety of in vivo and ex vivo approaches. The candidate will perform experiments that include basic molecular and biochemical bench-work, generate plasmids and produce retrovirus/lentivirus, and perform cell culture of mouse and human cells. The candidate will contribute to scientific publications, patents, and funding proposals as needed.

The candidate will report to Dr. Evgin, the principal investigator, but is expected to operate independently on a daily basis. Results will be reviewed and additional experiments outlined on a weekly basis. The candidate will regularly interact with members of the Evgin lab regarding data generation and project coordination as well as members from collaborating research labs. The candidate will attend weekly meetings of laboratory workers and regularly present results.

Qualifications

• A Ph.D. degree in an appropriate discipline
• A strong background in molecular biology including DNA isolation/purification, construct design, and cloning is desirable.
• Experience working with primary immune cells and along with CRISPR-based genetic engineering is desirable.
• Experience with flow cytometry and standard immunologic techniques is desirable.
• Experience with mouse handling and injections is helpful but not essential.
• Experience with retro or lentivirus based viral vectors is helpful but not essential.
• Experience with mRNA or LNP delivery is helpful but not essential.
• Experience using graphing programs such as Prism, Excel, etc. is important.
• Outstanding organization skills and attention to detail is essential as well as the ability to efficiently manage time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities.
• Ability for critical thinking and independent learning.
• Ability to collaborate proficiently and communicate effectively with colleagues and management teams. Experience in a supervisory role is an asset. 

Benefits

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That is why we are focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the BC Cancer group benefits plan, which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

100% onsite

Salary Range: 

$50,000 to $55,000 p.a.

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan. 

Apply

Please submit a detailed cover letter and resume highlighting relevant research experience, interests and goals; and the names and contact details of three references to bcgscjobs@bcgsc.ca , using PDF_01553_Evgin Lab_2024_06_06 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

 

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders  in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first  publication  to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No. RA2_R00004_Proteomics_2024_06_03

Summary

The proteomics core facility at the Genome Sciences Centre assists a diverse base of collaborators and clients to characterize and quantify the changes in  the proteome that drive disease, particularly in cancer. Our work is multidisciplinary in nature, utilizing state-of-the-art mass spectrometry instrumentation and novel methodologies to identify and validate proteins that can act as therapeutic targets and biomarkers for the translation of genomic information into clinical practice.

The Research Assistant of the proteomics core facility will primarily be responsible for preparation of clinical and research samples for proteomic analysis. The position is within a multidisciplinary team that supports fostering scientific and personal development and learning within individuals and the group. The Research Assistant works together with the Facility Manager, staff scientists, and students to plan, coordinate, conduct and report on mass spectrometry based research projects. The successful candidate will have exemplary wet lab skills , organization, communication, and teamwork and be excited to work in a collaborative, multidisciplinary setting.

Duties

Administrative

• Maintaining data logs of samples analyzed and instrument use
• Liaising with collaborators to coordinate sample submission and communicating results
• Communicating and maintaining contact with client lab personnel
• Maintaining a detailed lab notebook
• Maintains and communicates inventory of laboratory supplies and equipment.

Technical

• Preparing samples for proteomic analysis by following a variety of established technical procedures according to written protocols.

• May operating facility instrumentation including off-line HPLC fractionation systems, mass spectrometers, speed vacs, and related instrumentation
• Performing initial data analysis
• May assist in the modification, development, and implementation of cutting edge protocols for clinical proteomics
• Maintains and stores cell lines and primary cultures.
• Maintains and stores test materials and products.

• Assisting facility staff and collaborators with results dissemination.

Qualifications

• Knowledge of tandem mass spectrometry and reversed phase chromatography (HPLC and nanoLC)
• Experience in the handling of cells, tissues, and/or clinical samples
• Practical experience with liquid chromatography, mass spectrometry instrumentation, proteomics sample preparation an asset

The applicant is expected to have a level of education, training, and experience equivalent to a BSc + 2 years of experience in an appropriate discipline or similar.

Benefits

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the BC Cancer group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type

Temporary renewable, Full-Time, 7.5 hrs. per day

100% onsite

Salary Range

$57,347 to $75,268

The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan. 

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. RA2_R00004_Proteomics_2024_06_03 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

 

About the GSC

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Computational Biologist, Clinical

Job Reference no: CB_P01060_HSA166907_CCG_2023_05_31

Canada’s Michael Smith Genome Sciences Centre (GSC) is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility. If you have a Bachelor of Applied Science or a Bachelor of Science in biological science or computer science, as well as an interest in programming and human health, this is your opportunity to become involved in a team working with cutting-edge technology as a Clinical Computational Biologist.

As a Computational Biologist, you will perform bioinformatics analyses and contribute to software development related to the operation of a large-scale clinical sequencing facility. The position is anchored within a team of exceptional scientists, computational biologists and programmers, which collaborate directly on the development of robust, cost efficient and competitive processes for new targeted and precision medicine analytical pipelines. Your work will help to save lives and contribute to a world free from the fear of cancer.

By working within the GSCs bioinformatics facility, the successful applicant will develop close relationships with world-renown computational and genome science technologists, cancer researchers and medical scientists; have access to one of the most robust computational and next generation genome sequencing technology facilities in Canada, all while living in one of the most beautiful, diverse and eclectic cities in the world.

This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities.

Apply now!

Duties and Responsibilities

1. Contributes to the design, development, implementation, validation, running, and maintenance of clinical bioinformatics pipelines and related databases.
2. Contributes to incorporation of third-party software into clinical bioinformatics pipelines, including:
   • identifying candidate software to consider
   • comparing software candidates to aid in selection
   • determining optimal parameters for the chosen software
   • developing interfaces to integrate the chosen software and
   • validating integration of the chosen software.
3. Participates in the development of novel software solutions, as directed by the Assistant Bioinformatics Coordinator or Clinical Bioinformatics Coordinator.
4. Participates in peer code review.
5. Contributes to writing and updating official procedures and other documentation related to clinical bioinformatics pipelines.
6. Verifies results produced by clinical bioinformatics pipelines.
7. Performs exploratory analyses to identify potential root causes of issues encountered during production processing, and implements corrective actions as directed by the Assistant Bioinformatics Coordinator or Clinical Bioinformatics Coordinator.
8. Performs bioinformatics analyses to answer questions from the Clinical Director, Clinical Bioinformatics Coordinator, or Assistant Bioinformatics Coordinator.
9. Presents implementation plans, analysis results, and validation results internally and externally, in oral presentations and written documentation.
10. Contributes to the development of research papers by providing materials, methods, and/or analyzed data.
11. Participates in the training of others through orientation, informal instruction, and sharing of job information.
12. Performs other related duties as required.

Qualifications

Education, Training and Experience

• Graduation from a recognized Bachelor of Applied Science or Bachelor of Science Program in either Biological Sciences or Computer Science.
• Two (2) years of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Demonstrated skill with Python or other similar high level languages.
• Functional knowledge of distributed version control systems, such as Git.
• Demonstrated ability in R or other similar statistical programming languages.
• Familiarity with relational databases, such as PostgreSQL, and with ORMs.
• Ability to program and run analyses in a production environment.
• Excellent verbal and written communication skills.
• Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments to complete required tasks on time.
• Familiarity with next-generation sequencing, cancer genetics, principles of clinical testing, experimental design, statistical hypothesis testing, and/or machine learning would be considered an asset.
• Ability to use related equipment.

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the BC Cancer group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Regular Full-Time, 7.5 hrs. per day

Salary Range: 

Starting at $37.89 to $47.20 per hour for the 6^th year

The salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan and the HSA Collective Agreement.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference no: CB_P01060_HSA166907_CCG_2023_05_31 in the subject line of your email.

As this is a union position, you will also have to apply either as an internal or external applicant through http://www.phsa.ca/careers using the posting reference HSA166907.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No. GST_P00634_HSA165430_Library Core_2024_05_09

Canada’s Michael Smith Genome Sciences Centre (GSC) is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility. If you have a diploma in Biotechnology, Molecular Biology or Biochemistry and experience working in a research lab, join our team as a Genome Science Technologist!  

At the GSC, Genome Science Technologists perform various molecular biology techniques and procedures using laboratory robots. This includes biospecimen procurement, sample handling and quality control, diverse library construction and high throughput sequencing methods.

The position is anchored within a team of exceptional scientists, computational biologists and programmers, which collaborate directly on the development of robust, cost efficient, and competitive processes for new targeted and precision medicine analytical pipelines. By working within the GSCs Biospecimen Core, you will develop close relationships with world-renowned specialists in bioinformatics, cancer researchers and medical scientists; have access to one of the most robust computational and next generation genome sequencing technology facilities in Canada, all while living in one of the most beautiful, diverse and eclectic cities in the world. Your work will help to save lives and contribute to a world free from the fear of cancer.

This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities.

This is a temporary full-time renewable union position.

Apply now!

Duties and Responsibilities

1. Following controlled laboratory procedures, performs tasks such as biospecimen receipt and quality assessments, laboratory information management system (LIMS) data entry, RNA and DNA purification, cDNA synthesis, genome and transcriptome next generation library construction and sequencing.
2. Works within a regulated quality management system including maintaining training records, document control with active corrective and preventative actions (CA/PA).
3. Data entry using laboratory software and basic reporting of results to supervisors.
4. Prepares solutions following standard operating procedures.
5. Maintains general lab and equipment cleanliness.  Recognizes and reports malfunctions in equipment.
6. Processes patient samples according to established procedures for clinical sequencing diagnostic tests.
7. Performs other related duties as required.

Qualifications

Education, Training and Experience

Graduation from a recognized diploma program in Biotechnology, Molecular Biology or Biochemistry 

- OR -

An equivalent combination of education, training and experience acceptable to the Genome Sciences Centre Group Leaders and Production Coordinators.

Skills and Abilities

• Knowledge of molecular biology techniques, particularly DNA and RNA preparation and manipulation, and a good understanding of genomics technologies.
• Demonstrated ability to perform detailed procedures reproducibly and accurately.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments and establish priorities.
• Basic knowledge of and ability to operate personal computers.

Benefits:

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the BC Cancer group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 18 month leave replacement, 7.5 hrs. per day

100% onsite

Wage:

Starting at $36.59 to $45.55 per hour for the 6^th year

The salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan and the HSA Collective Agreement.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. GST_P00634_HSA165430_Library Core_2024_05_09 in the subject line of your email.

As this is a union position, you will also have to apply either as an internal or external applicant through http://www.phsa.ca/careers using the posting reference 165430.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

Job Reference No.  PDF_01553_Jones Lab_2024_03_14

Canada’s Michael Smith Genome Sciences Centre (GSC) is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility. As part of the Earth BioGenome Project (EBP) secretariat, GSC plays a pivotal role in steering this monumental initiative aiming to sequence all life on Earth. We are currently looking for a Post Doctoral Fellow (PDF) to work as the EBP’s Genomic Insights Coordinator funded by Genome British Columbia. 

In this role, you will support the EGP Secretariat which is located at the Arizona State University and supported by the GSC – BC Cancer, Genome BC, Sanger Institute and Monell Foundation and will work closely together with Earth BioGenome Project (EBP) consortium on the sequencing and assembly standards.

The position is anchored within a team of exceptional scientists, computational biologists and programmers, which collaborate directly on improving genome sequencing technology, interpretation and application. Working with Dr. Steven Jones and the group at the GSC, you will develop close relationships with world-renown specialists in genomics and bioinformatics and have access to one of the most robust computational and next generation genome sequencing technology facilities in Canada, all while living in one of the most beautiful, diverse and eclectic cities in the world. 

Duties

• Improve Communication on EBP data by utilizing various media platforms to engage with end-users.
• Enhance literacy through educational workshops and development of resources. This will be done in collaboration with academic institutions.
• Develop or collaborate on portals where users can access data tools easily.
• Set up training sessions on how to navigate these portals.
• Develop methods to ensure that the data can be easily integrated into analytical processes of the end-users.
• Engage with Key Rightsholders and Stakeholders by setting up meetings and focus groups with representatives from biodiversity, taxonomy, conservation, academic health research and industry sectors to understand their unique needs.
• Work actively with end-users to ensure access to latest biodiversity research and provide resources to support understanding such organisms and conservation efforts.
• Perform literature searches, testing and validation of new data analysis software related to bioinformatics interpretation of genomes.
• Represent the project within the global EBP consortium and contribute to the development of outreach materials and website information.
• Collaborate with the Project Leader to ensure all scientific milestones are achieved and contribute to progress reporting as required.
• Pursue opportunities for further research on the genomic information developed and scholarly publication.
• Perform other related duties as required.

Qualifications

• Expertise in bioinformatics, emphasizing genome sequence analysis and gene annotation.
• Knowledge and experience using scientific tools, technologies and online resources as pertaining to de-novo genome assembly.
• Fluency in multiple programming languages, including Python, Javascript and SQL desirable.
• Expertise developing and operating in a UNIX/Linux environment and writing shell scripts.
• Experience developing custom scripts and pipelines using high performance computing and other available tools. Pipelines may include de novo assembly, annotation, database query, pan-genome construction and visualization tools, RNA-seq and phylogenetic tree reconstruction.
• Excellent communication and organization skills, and ability to efficiently manage time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities.
• Ability for critical thinking and independent learning.
• Experience in a supervisory role is an asset.  

Benefits

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.

• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the BC Cancer group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Temporary Full-Time, 7.5 hrs. per day

Salary Range: 

$58,000 p.a. The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan. 

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using PDF_01553_Jones Lab_2024_03_14 in the subject line of your email. This position will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No. ABC_P00183_HSA154648_Software Development_2024_01_16

Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.
The Assistant Bioinformatics Coordinator provides supervisory and technical support to the Bioinformatics group of the Genome Sequence Centre (GSC). Ensures that the day-to-day activities of a large scale, high throughput facility meet research, data analysis throughput and software development objectives.

Duties

1. Assists the Bioinformatics Coordinator in the day to day activities of the Bioinformatics group by performing duties such as providing input on quantity and quality of work, making recommendations for improvements, workflow and procedures.
2. Coordinates projects of the Bioinformatics group by performing duties such as chairing project-specific meetings and provides project status reports to the Bioinformatics Coordinator, with suggestions towards any required improvement of project management, task allocation and overall process.
3. Develops and implements assays to monitor project progress and measure project accomplishments to ensure that appropriate project focus is maintained and to provide feedback to staff.
4. Provides supervisory support to the Bioinformatics group by performing duties such as:
    a. Orientating new staff.
    b. Providing input to the Bioinformatics Coordinator on training requirements.
    c. Providing input to the Production Coordinator on the establishment of clear definitions of responsibility for employees.
    d. Assigning workload assignments and establishing work schedules.
    e. Reviewing and establishing work priorities and adjusting work schedules to ensure priorities are met.

    f. Completing performance reviews and addressing performance issues in conjunction with the Production Coordinator.
5. Participates in the recruitment of staff through methods such as interviewing internal and external applicants and forwards hiring recommendations.
6. Participates in the development and implementation of quality improvement programs to ensure services are provided in the most efficient and effective way by performing duties such as:
a. Monitoring quality and quantity of service and information provided by the bioinformatics group and identifying areas for change and/or improvement.
b. Generating test metrics to evaluate progress of research programs.
7. Assesses practical needs for identified research direction of the GSC in conjunction with the Bioinformatics Coordinator and Analysis Group Leader.
8. Participates in a variety of meetings by performing duties such as providing and/or receiving information and contributing to decision making.
9. Participates, in conjunction with the Bioinformatics Coordinator, in determining the computer infrastructure necessary for successful completion of projects and ensured viability of research programs by performing duties such as providing input and recommendations regarding purchasing decisions related to hardware, software and related items for the Bioinformatics platform.
10. Interprets statistical analyses and makes recommendations for review including preparing reports on statistical findings for publication and presentation in HTML format or as advised.
11. Conducts feasibility studies for computerization by performing duties such as determining user requirements, examining and identifying problems with existing systems and recommending modifications to and/or new systems; provides details of estimated implementation costs including associated staffing requirements.
12. Performs technical functions related to the bioinformatic functions of the GSC.
13. Performs other related duties as required.

Qualifications

Education, Training and Experience

• Graduation from a recognized Bachelor’s program in a related discipline such as Biochemistry, Genetics, Computer Science, Electrical Engineering or Physics.
• A minimum of four (4) years of recent related experience including experience in computer programming and quantitative data analysis, handling biological sequence and/or mapping data, database development and data storage schemas or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Experience with computer operating systems such as Linux, UNIX.
• Demonstrated ability to work with software such as C, C++, Perl , Matlab, MySQL.
• Demonstrated ability to accept responsibility and work independently.
• Demonstrated ability to work effectively with others in a team environment.
• Demonstrated ability to supervise staff and schedule work.
• Excellent organizational, leadership interpersonal and communication skills.
• Physical ability to perform the duties of the job.

Benefits

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the BC Cancer group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Regular, Full-Time, 7.5 hrs. per day

Wage: 

$39.26 to $48.88 per hour for the 6th year

The salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan and the HSA Collective Agreement.

Application

As this is a union position, you will also have to apply either as an internal or external applicant through http://www.phsa.ca/careers using the posting reference 154648.

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. ABC_P00183_HSA154648_Software Development_2024_01_16 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based onsite in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.