Projects
Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers that frequently arise in the kidney and the brain. The overall survival rate is poor, due to the lack of effective treatments. Nearly all MRTs harbor loss of SMARCB1, which is a core subunit of the chromatin-remodeling SWI/SNF complex that plays an important role in epigenomic and transcriptomic regulation. We aim to understand the effect of SMARCB1 loss on chromatin structure and regulatory changes using genetic and epigenetic approaches