Trainees: 

  • Elizabeth Chun, PhD Candidate 

    • Malignant rhabdoid tumours (MRT) are aggressive pediatric solid cancers driven by loss of SMARCB1. To study deregulated transcriptional and epigenetic regulatory networks in MRT, we perform integrative bioinformatics analyses of whole genome, transcriptome, miRNA, genome-wide DNA methylation and histone modifications in primary patient tissues and cell lines. Our analyses have revealed molecular heterogeneity in MRT, and shown evidence for deregulated pathways underpinning MRT pathology.

  • Dr. Dan Jin, Post-Doctoral Fellow 

    • Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers that frequently arise in the kidney and the brain. The overall survival rate is poor, due to the lack of effective treatments. Nearly all MRTs harbor loss of SMARCB1, which is a core subunit of the chromatin-remodeling SWI/SNF complex that plays an important role in epigenomic and transcriptomic regulation. We aim to understand the effect of SMARCB1 loss on chromatin structure and regulatory changes using genetic and epigenetic approaches

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