A genomics approach was undertaken to determine a signature profile of genes that are differentially expressed in chemotherapy resistance in colorectal cancers. Unique signatures were identified that are specific to 5-fluorouracil, irinotecan, etoposide and cisplatin resistance in colorectal cancers, as well as a profile that represents "global" resistance to chemotherapy. The overall goal of this project will be to develop a "Genomics Map" of Cancer Therapy Resistance. In order to achieve this objective, Dr. Tai's laboratory is systematically delineating the importance of these differentially expressed genes in chemo- and radiation therapy resistance in gastrointestinal cancers.